CATH Classification

CATH Clusters

Superfamily 1.25.40.10
Functional Family Peptidyl-prolyl cis-trans isomerase FKBP4

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q02790
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q02790
FKBP4_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP4

PDB Structure

PDB 1QZ2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Wu, B., Li, P., Liu, Y., Lou, Z., Ding, Y., Shu, C., Ye, S., Bartlam, M., Shen, B., Rao, Z.
Proc.Natl.Acad.Sci.USA