CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Ribosomal RNA small subunit methyltransferase A |
Enzyme Information
| 2.1.1.182 |
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase.
based on mapping to UniProt P06992
4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
-!- KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. -!- Strains lacking the methylase are resistant to kasugamycin. -!- Formerly EC 2.1.1.48.
|
UniProtKB Entries (1)
| P06992 |
RSMA_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase A
|
PDB Structure
| PDB | 1QYR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli
J.Mol.Biol.
|