CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family Calpain-1 catalytic subunit

Enzyme Information

3.4.22.52
Calpain-1.
based on mapping to UniProt P97571
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.
3.4.22.53
Calpain-2.
based on mapping to UniProt Q07009
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

Q07009
CAN2_RAT
Rattus norvegicus
Calpain-2 catalytic subunit

PDB Structure

PDB 1QXP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of a mu-like calpain reveals a partially activated conformation with low Ca(2+) requirement
Pal, G.P., Veyra, T.D., Elce, J.S., Jia, Z.
Structure