CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

3.4.11.5
Prolyl aminopeptidase.
based on mapping to UniProt O32449
Release of N-terminal proline from a peptide.
-!- Present in the cytosol of mammalian and microbial cells. -!- In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide. -!- The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1. -!- Belongs to peptidase family S33. -!- Formerly EC 3.4.1.4.

UniProtKB Entries (1)

O32449
PIP_SERMA
Serratia marcescens
Proline iminopeptidase

PDB Structure

PDB 1QTR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of prolyl aminopeptidase from Serratia marcescens.
Yoshimoto, T., Kabashima, T., Uchikawa, K., Inoue, T., Tanaka, N., Nakamura, K.T., Tsuru, M., Ito, K.
J.Biochem.(Tokyo)