CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt Q26997
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.22
Xanthine phosphoribosyltransferase.
based on mapping to UniProt Q26997
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.

UniProtKB Entries (1)

Q26997
HGXR_TOXGO
Toxoplasma gondii
Hypoxanthine-guanine-xanthine phosphoribosyltransferase

PDB Structure

PDB 1QK3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase Gmp and -Imp Complexes: Comparison of Purine Binding Interactions with the Xmp Complex
Heroux, A., White, E.L., Ross, L.J., Borhani, D.W.
Biochemistry