CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Ribosome-inactivating protein saporin-6

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P20656
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P20656
RIP6_SAPOF
Saponaria officinalis
Ribosome-inactivating protein saporin-6

PDB Structure

PDB 1QI7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome.
Savino, C., Federici, L., Ippoliti, R., Lendaro, E., Tsernoglou, D.
FEBS Lett.