CATH Domain 1qdmA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Aspartic proteinase A1

Enzyme Information

3.4.23.40

Phytepsin.

based on mapping to UniProt P42210

Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-|-Asp- and -Asp-|-Asp- bonds in 2S albumin from plant seeds.

-!- Known particularly fron barley grain, but present in other plants also. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P42210

ASPR_HORVU

Hordeum vulgare

Phytepsin

PDB Structure

PDB	1QDM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting. Kervinen, J., Tobin, G.J., Costa, J., Waugh, D.S., Wlodawer, A., Zdanov, A. EMBO J.