CATH Domain 1qbgA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	NAD(P)H dehydrogenase [quinone] 1

Enzyme Information

1.6.5.2

NAD(P)H dehydrogenase (quinone).

based on mapping to UniProt P15559

NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.

-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P15559

NQO1_HUMAN

Homo sapiens

NAD(P)H dehydrogenase [quinone] 1

PDB Structure

PDB	1QBG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). Skelly, J.V., Sanderson, M.R., Suter, D.A., Baumann, U., Read, M.A., Gregory, D.S., Bennett, M., Hobbs, S.M., Neidle, S. J.Med.Chem.