CATH Classification

Domain Context

CATH Clusters

Superfamily Ribosomal RNA adenine dimethylase-like, domain 2
Functional Family

Enzyme Information

2.1.1.184
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
based on mapping to UniProt P13956
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
-!- ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085). -!- Formerly EC 2.1.1.48.

UniProtKB Entries (1)

P13956
ERM_BACIU
Bacillus subtilis
RRNA adenine N-6-methyltransferase

PDB Structure

PDB 1QAO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C.
J.Mol.Biol.