CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.184 |
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
based on mapping to UniProt P13956
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
-!- ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085). -!- Formerly EC 2.1.1.48.
|
UniProtKB Entries (1)
| P13956 |
ERM_BACIU
Bacillus subtilis
RRNA adenine N-6-methyltransferase
|
PDB Structure
| PDB | 1QAM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol.
|