CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.880 | Class I glutamine amidotransferase (GATase) domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.880 |
| Functional Family | uncharacterized protein LOC100176842 isoform X2 |
Enzyme Information
| 4.3.3.6 |
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
based on mapping to UniProt P83813
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.
-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.
|
| 3.5.1.2 |
Glutaminase.
based on mapping to UniProt P83813
L-glutamine + H(2)O = L-glutamate + NH(3).
|
UniProtKB Entries (1)
| P83813 |
PDXT_GEOSE
Geobacillus stearothermophilus
Pyridoxal 5'-phosphate synthase subunit PdxT
|
PDB Structure
| PDB | 1Q7R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
X-ray structure analysis of a predicted amidotransferase from B. stearothermophilus at 1.9 A resolution
To be Published
|