CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1410.10
Functional Family

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P25500
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P25500
PAPOA_BOVIN
Bos taurus
Poly(A) polymerase alpha

PDB Structure

PDB 1Q78
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
Martin, G., Moglich, A., Keller, W., Doublie, S.
J.Mol.Biol.