CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P45523
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P45523
FKBA_ECOLI
Escherichia coli K-12
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

PDB Structure

PDB 1Q6I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity.
Saul, F.A., Arie, J.P., Vulliez-le Normand, B., Kahn, R., Betton, J.M., Bentley, G.A.
J.Mol.Biol.