1 keywords

CATH Domain 1pzvA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.10 Roll
Topology 3.10.110 Ubiquitin Conjugating Enzyme
Homologous Superfamily 3.10.110.10 Ubiquitin Conjugating Enzyme

Domain Context

CATH Clusters

Superfamily Ubiquitin Conjugating Enzyme
Functional Family Ubiquitin-conjugating enzyme E2 G1

Enzyme Information

2.3.2.23
E2 ubiquitin-conjugating enzyme.
based on mapping to UniProt P34477
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine.
-!- The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. -!- In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. -!- Formerly EC 6.3.2.19.

UniProtKB Entries (1)

P34477
UBC7_CAEEL
Caenorhabditis elegans
Probable ubiquitin-conjugating enzyme E2 7

PDB Structure

PDB 1PZV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans
Schormann, N., Lin, G., Li, S., Symersky, J., Qiu, S., Finley, J., Luo, D., Stanton, A., Carson, M., Luo, M., DeLucas, L., Pruett, P., Nagy, L., Arabashi, A., Gray, R., Johnson, D., Tsao, J., Bunzel, B., Huang, W., Shang, Q., Luan, C.-H., Lu, S., Zhang, J., McKinstry, A., Chen, H.
To be Published