CATH Classification

Domain Context

CATH Clusters

Superfamily Toxin ADP-ribosyltransferase; Chain A, domain 1
Functional Family

Enzyme Information

3.4.24.83
Anthrax lethal factor endopeptidase.
based on mapping to UniProt P15917
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917
LEF_BACAN
Bacillus anthracis
Lethal factor

PDB Structure

PDB 1PWV
External Links
Method X-RAY DIFFRACTION
Organism Bacillus
Primary Citation
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Turk, B.E., Wong, T.Y., Schwarzenbacher, R., Jarrell, E.T., Leppla, S.H., Collier, R.J., Liddington, R.C., Cantley, L.C.
Nat.Struct.Mol.Biol.