CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family 8-oxo-dGTP diphosphatase MutT

Enzyme Information

3.6.1.55
8-oxo-dGTP diphosphatase.
based on mapping to UniProt P08337
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

P08337
MUTT_ECOLI
Escherichia coli K-12
8-oxo-dGTP diphosphatase

PDB Structure

PDB 1PUQ
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
Massiah, M.A., Saraswat, V., Azurmendi, H.F., Mildvan, A.S.
Biochemistry