CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD(P) transhydrogenase subunit beta

Enzyme Information

7.1.1.1
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt Q13423
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.

UniProtKB Entries (1)

Q13423
NNTM_HUMAN
Homo sapiens
NAD(P) transhydrogenase, mitochondrial

PDB Structure

PDB 1PT9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation
Singh, A., Venning, J.D., Quirk, P.G., Van Boxel, G.I., Rodrigues, D.J., White, S.A., Jackson, J.B.
J.Biol.Chem.