CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.37
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P08246
ELNE_HUMAN
Homo sapiens
Neutrophil elastase

PDB Structure

PDB 1PPG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor.
Wei, A.Z., Mayr, I., Bode, W.
FEBS Lett.