CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family Sterol 3-beta-glucosyltransferase UGT80A2

Enzyme Information

2.4.1.311
dTDP-epi-vancosaminyltransferase.
based on mapping to UniProt P96558
dTDP-beta-L-4-epi-vancosamine + devancoaminyl-vancomycin = dTDP + chloroorienticin B.
-!- The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.

UniProtKB Entries (1)

P96558
GTFA_AMYOR
Amycolatopsis orientalis
DTDP-epi-vancosaminyltransferase

PDB Structure

PDB 1PN3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Mulichak, A.M., Losey, H.C., Lu, W., Wawrzak, Z., Walsh, C.T., Garavito, R.M.
Proc.Natl.Acad.Sci.USA