CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.140.60
Functional Family

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P40136
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (2)

P40136
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase
P0DP25
CALM3_HUMAN
Homo sapiens
Calmodulin-3

PDB Structure

PDB 1PK0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Shen, Y., Zhukovskaya, N.L., Zimmer, M.I., Soelaiman, S., Bergson, P., Wang, C.R., Gibbs, C.S., Tang, W.J.
Proc.Natl.Acad.Sci.USA