CATH Classification

CATH Clusters

Superfamily 3.10.50.40
Functional Family PpiC-type peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q13526
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526
PIN1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB 1PIN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent.
Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P.
Cell(Cambridge,Mass.)