CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P00349
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P00349
6PGD_SHEEP
Ovis aries
6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB 1PGP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
Adams, M.J., Ellis, G.H., Gover, S., Naylor, C.E., Phillips, C.
Structure