CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family

Enzyme Information

1.1.1.80
Isopropanol dehydrogenase (NADP(+)).
based on mapping to UniProt P25984
Propan-2-ol + NADP(+) = acetone + NADPH.
-!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.

UniProtKB Entries (1)

P25984
ADH_CLOBE
Clostridium beijerinckii
NADP-dependent isopropanol dehydrogenase

PDB Structure

PDB 1PED
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystalline alcohol dehydrogenases from the mesophilic bacterium Clostridium beijerinckii and the thermophilic bacterium Thermoanaerobium brockii: preparation, characterization and molecular symmetry.
Korkhin, Y., Frolow, F., Bogin, O., Peretz, M., Kalb, A.J., Burstein, Y.
Acta Crystallogr.,Sect.D