CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.30
Caricain.
based on mapping to UniProt P10056
Hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain.
-!- From the papaya plant, Carica papaya. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P10056
PAPA3_CARPA
Carica papaya
Caricain

PDB Structure

PDB 1PCI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Groves, M.R., Taylor, M.A., Scott, M., Cummings, N.J., Pickersgill, R.W., Jenkins, J.A.
Structure