CATH Classification

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Papain family cysteine protease

Enzyme Information

3.4.22.2
Papain.
based on mapping to UniProt P00784
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
-!- From latex of the papaya (Carica papaya). -!- Inhibited by compound E-64 and proteins of the cystatin family. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.10.

UniProtKB Entries (1)

P00784
PAPA1_CARPA
Carica papaya
Papain

PDB Structure

PDB 1PAD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding of chloromethyl ketone substrate analogues to crystalline papain.
Drenth, J., Kalk, K.H., Swen, H.M.
Biochemistry