CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family 23S rRNA methyltransferase A

Enzyme Information

2.1.1.187
23S rRNA (guanine(745)-N(1))-methyltransferase.
based on mapping to UniProt P36999
S-adenosyl-L-methionine + guanine(745) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(745) in 23S rRNA.
-!- The enzyme specifically methylates guanine(745) at N(1) in 23S rRNA. -!- Formerly EC 2.1.1.51.

UniProtKB Entries (1)

P36999
RLMA_ECOLI
Escherichia coli K-12
23S rRNA (guanine(745)-N(1))-methyltransferase

PDB Structure

PDB 1P91
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.
Das, K., Acton, T., Chiang, Y., Shih, L., Arnold, E., Montelione, G.T.
Proc.Natl.Acad.Sci.Usa