CATH Classification

Domain Context

CATH Clusters

Superfamily Malate synthase G - maily-beta sub-domain
Functional Family

Enzyme Information

2.3.3.9
Malate synthase.
based on mapping to UniProt P37330
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P37330
MASZ_ECOLI
Escherichia coli K-12
Malate synthase G

PDB Structure

PDB 1P7T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Escherichia Coli Malate Synthase G:pyruvate:acetyl-coenzyme A Abortive Ternary Complex at 1.95 Angstrom Resolution
Anstrom, D.M., Kallio, K., Remington, S.J.
Protein Sci.