CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.287.440
Functional Family Bifunctional purine biosynthesis protein PURH

Enzyme Information

2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31939
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt P31939
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

P31939
PUR9_HUMAN
Homo sapiens
Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB 1P4R
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
Cheong, C.-G., Wolan, D.W., Greasley, S.E., Horton, P.A., Beardsley, G.P., Wilson, I.A.
J.Biol.Chem.