CATH Classification

Domain Context

CATH Clusters

Superfamily Riboflavin kinase-like
Functional Family Riboflavin kinase, putative

Enzyme Information

2.7.1.26
Riboflavin kinase.
based on mapping to UniProt Q969G6
ATP + riboflavin = ADP + FMN.
-!- The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B(6), vitamin B12 and folates. -!- While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2. -!- In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP.

UniProtKB Entries (1)

Q969G6
RIFK_HUMAN
Homo sapiens
Riboflavin kinase

PDB Structure

PDB 1P4M
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Human Riboflavin Kinase Reveals a Beta Barrel Fold and a Novel Active Site Arch
Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N.V., Osterman, A.L., Zhang, H.
Structure