CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Cysteine desulfurase IscS

Enzyme Information

2.8.1.7
Cysteine desulfurase.
based on mapping to UniProt P0A6B7
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.
-!- The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. -!- The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin). -!- In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.

UniProtKB Entries (1)

P0A6B7
ISCS_ECOLI
Escherichia coli K-12
Cysteine desulfurase IscS

PDB Structure

PDB 1P3W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of IscS, a Cysteine Desulfurase from Escherichia coli
Cupp-Vickery, J.R., Urbina, H., Vickery, L.E.
J.Mol.Biol.