CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P49023
PAXI_HUMAN
Homo sapiens
Paxillin

PDB Structure

PDB 1OW6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular Recognition of Paxillin LD motifs by the Focal Adhesion Targeting Domain
Hoellerer, M.K., Noble, M.E.M., Labesse, G., Campbell, I.D., Werner, J.M., Arold, S.T.
Structure