CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P0C0E6
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P0C0E6
KITH_VZVO
Human herpesvirus 3 strain Oka vaccine
Thymidine kinase

PDB Structure

PDB 1OSN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of varicella zoster virus thymidine kinase
Bird, L.E., Ren, J., Wright, A., Leslie, K.D., Degreve, B., Balzarini, J., Stammers, D.K.
J.Biol.Chem.