CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonucleotide Reductase, subunit A
Functional Family Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic

Enzyme Information

1.14.19.2
Stearoyl-[acyl-carrier-protein] 9-desaturase.
based on mapping to UniProt P22337
Stearoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O(2) + 2 H(+) = oleoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.
-!- The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. -!- The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. -!- It also acts on palmitoyl-[acyl-carrier-protein]. -!- Formerly EC 1.14.99.6.

UniProtKB Entries (1)

P22337
STAD_RICCO
Ricinus communis
Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic

PDB Structure

PDB 1OQ4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Azide and acetate complexes plus two iron-depleted crystal structures of the di-iron enzyme delta 9 stearoyl-ACP desaturase- implications for oxygen activation and catalytic intermediates.
Moche, M., Shanklin, J., Ghoshal, A., Lindqvist, Y.
J.Biol.Chem.