CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1740.10
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt P45568
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P45568
DXR_ECOLI
Escherichia coli K-12
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 1ONP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F.
J.BIOL.CHEM.