CATH Classification

Domain Context

CATH Clusters

Superfamily RutC-like
Functional Family

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P52758
3.5.99.10
2-iminobutanoate/2-iminopropanoate deaminase.
based on mapping to UniProt P52758
(1) 2-iminobutanoate + H(2)O = 2-oxobutanoate + NH(3). (2) 2-iminopropanoate + H(2)O = pyruvate + NH(3).
-!- This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. -!- The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.

UniProtKB Entries (1)

P52758
RIDA_HUMAN
Homo sapiens
2-iminobutanoate/2-iminopropanoate deaminase

PDB Structure

PDB 1ONI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Homo sapiens protein hp14.5.
Manjasetty, B.A., Delbruck, H., Pham, D.T., Mueller, U., Fieber-Erdmann, M., Scheich, C., Sievert, V., Bussow, K., Niesen, F.H., Weihofen, W., Loll, B., Saenger, W., Heinemann, U., Neisen, F.H.
Proteins