CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt Q8MU52
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

Q8MU52
GST_PLAFA
Plasmodium falciparum
Glutathione S-transferase

PDB Structure

PDB 1OKT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium Falciparum
Fritz-Wolf, K., Becker, A., Rahlfs, S., Harwaldt, P., Schirmer, R.H., Kabsch, W., Becker, K.
Proc.Natl.Acad.Sci.USA