CATH Classification

Domain Context

CATH Clusters

Superfamily 5'-Nucleotidase, C-terminal domain
Functional Family Trifunctional nucleotide phosphoesterase protein

Enzyme Information

3.1.3.5
5'-nucleotidase.
based on mapping to UniProt P07024
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
3.6.1.45
UDP-sugar diphosphatase.
based on mapping to UniProt P07024
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
-!- UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. -!- Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21. -!- Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.

UniProtKB Entries (1)

P07024
USHA_ECOLI
Escherichia coli K-12
Protein UshA

PDB Structure

PDB 1OI8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Trapping a 96 Degree Domain Rotation in Two Distinct Conformations by Engineered Disulfide Bridges
Schultz-Heienbrok, R., Maier, T., Straeter, N.
Protein Sci.