CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.22
(S)-3-amino-2-methylpropionate transaminase.
based on mapping to UniProt P80147
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate.
-!- Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. -!- The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
2.6.1.19
4-aminobutyrate--2-oxoglutarate transaminase.
based on mapping to UniProt P80147
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.

UniProtKB Entries (1)

P80147
GABT_PIG
Sus scrofa
4-aminobutyrate aminotransferase, mitochondrial

PDB Structure

PDB 1OHW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin
Storici, P., De Biase, D., Bossa, F., Bruno, S., Mozzarelli, A., Peneff, C., Silverman, R., Schirmer, T.
J.Biol.Chem.