CATH Domain 1ogsA02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1180	Golgi alpha-mannosidase II

Domain Context

CATH Clusters

Superfamily	Golgi alpha-mannosidase II
Functional Family

Enzyme Information

2.4.1.-	Hexosyltransferases. based on mapping to UniProt P04062
3.2.1.104	Steryl-beta-glucosidase. based on mapping to UniProt P04062 Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. -!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45	Glucosylceramidase. based on mapping to UniProt P04062 D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine. -!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

GLCM_HUMAN

Homo sapiens

Lysosomal acid glucosylceramidase

PDB Structure

PDB	1OGS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-Ray Structure of Human Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease Dvir, H., Harel, M., Mccarthy, A.A., Toker, L., Silman, I., Futerman, A.H., Sussman, J.L. Embo Rep.