CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cyclin-dependent kinase 5 homolog

Enzyme Information

2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt Q07785
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q07785
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q07785
CDC2H_PLAFK
Plasmodium falciparum K1
Cell division control protein 2 homolog

PDB Structure

PDB 1OB3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of P. Falciparum Pfpk5 Test the Cdk Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition
Holton, S., Merckx, A., Burgess, D., Doerig, C., Noble, M., Endicott, J.
Structure