CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Primary amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46883
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46883
AMO_ECOLI
Escherichia coli K-12
Primary amine oxidase

PDB Structure

PDB 1OAC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.
Parsons, M.R., Convery, M.A., Wilmot, C.M., Yadav, K.D., Blakeley, V., Corner, A.S., Phillips, S.E., McPherson, M.J., Knowles, P.F.
Structure