CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 1O5D
External Links
Method X-RAY DIFFRACTION
Organism Homo
Primary Citation
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
J.Mol.Biol.