CATH Classification

Domain Context

CATH Clusters

Superfamily Clavaminate synthase-like
Functional Family

Enzyme Information

1.14.20.3
(5R)-carbapenem-3-carboxylate synthase.
based on mapping to UniProt Q9XB59
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O(2) = (5R)-carbapen- 2-em-3-carboxylate + succinate + CO(2) + H(2)O.
-!- The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. -!- It catalyzes a stereoinversion at C(5) and introduces a double bond between C-2 and C-3.

UniProtKB Entries (1)

Q9XB59
CARC_PECCC
Pectobacterium carotovorum subsp. carotovorum
(5R)-carbapenem-3-carboxylate synthase

PDB Structure

PDB 1NX8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of carbapenem synthase (CarC).
Clifton, I.J., Doan, L.X., Sleeman, M.C., Topf, M., Suzuki, H., Wilmouth, R.C., Schofield, C.J.
J.Biol.Chem.