CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
Q846V4
Q846V4_STAAU
Staphylococcus aureus
Staphylocoagulase

PDB Structure

PDB 1NU7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
Friedrich, R., Panizzi, P., Fuentes-Prior, P., Richter, K., Verhamme, I., Anderson, P.J., Kawabata, S., Huber, R., Bode, W., Bock, P.E.
NATURE