CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.395 | Adenoviral Proteinase; Chain |
|
3.40.395.10 | Adenoviral Proteinase; Chain A |
Domain Context
CATH Clusters
| Superfamily | Adenoviral Proteinase; Chain A |
| Functional Family | Protease |
Enzyme Information
| 3.4.22.39 |
Adenain.
based on mapping to UniProt P03252
Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid).
-!- A cysteine endopeptidase from adenoviruses. -!- Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site. -!- Belongs to peptidase family C5.
|
UniProtKB Entries (1)
| P03252 |
PRO_ADE02
Human adenovirus 2
Protease
|
PDB Structure
| PDB | 1NLN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold
Biochim.Biophys.Acta
|