CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1NL1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Huang, M., Rigby, A.C., Morelli, X., Grant, M.A., Huang, G., Furie, B., Seaton, B., Furie, B.C.
Nat.Struct.Biol.