CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Short-chain dehydrogenase reductase

Enzyme Information

1.1.1.53
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase.
based on mapping to UniProt P9WGT1
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
-!- The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.

UniProtKB Entries (1)

P9WGT1
HSD_MYCTU
Mycobacterium tuberculosis H37Rv
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

PDB Structure

PDB 1NFR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis
Yang, J.K., Park, M.S., Waldo, G.S., Suh, S.W.
Proc.Natl.Acad.Sci.USA