CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.16
Cathepsin H.
based on mapping to UniProt O46427
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.
-!- Present in lysosomes of mammalian cells. -!- Because of the combination of endopeptidase and aminopeptidase activity it can be considered as 'endoaminopeptidase'. -!- Belongs to peptidase family C1.

UniProtKB Entries (2)

O46427
CATH_PIG
Sus scrofa
Pro-cathepsin H
P01040
CYTA_HUMAN
Homo sapiens
Cystatin-A

PDB Structure

PDB 1NB5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases
Jenko, S., Dolenc, I., Guncar, G., Dobersek, A., Podobnik, M., Turk, D.
J.Mol.Biol.