CATH Classification

Domain Context

CATH Clusters

Superfamily UDP-galactose 4-epimerase, domain 1
Functional Family GDP-mannose 4,6 dehydratase

Enzyme Information

4.2.1.47
GDP-mannose 4,6-dehydratase.
based on mapping to UniProt P93031
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.

UniProtKB Entries (1)

P93031
GMD2_ARATH
Arabidopsis thaliana
GDP-mannose 4,6 dehydratase 2

PDB Structure

PDB 1N7H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of the MUR1 GDP-mannose 4,6-dehydratase from A. thaliana: Implications for ligand binding and specificity.
Mulichak, A.M., Bonin, C.P., Reiter, W.-D., Garavito, R.M.
Biochemistry