CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1130.10
Functional Family GTP cyclohydrolase 1

Enzyme Information

3.5.4.16
GTP cyclohydrolase I.
based on mapping to UniProt P0A6T5
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.
-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.

UniProtKB Entries (1)

P0A6T5
GCH1_ECOLI
Escherichia coli K-12
GTP cyclohydrolase 1

PDB Structure

PDB 1N3S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I
Rebelo, J., Auerbach, G., Bader, G., Bracher, A., Nar, H., Hoesl, C., Schramek, N., Kaiser, J., Bacher, A., Huber, R., Fischer, M.
J.MOL.BIOL.